EGIS® is a cell-free, non-pyrogenic collagen matrix derived from porcine dermis (acellular dermal matrix ADM). EGIS® is available in both 0.8mm and 1.5mm thicknesses and is intended for use as a surgical membrane in soft tissue repairs and serves to support, cover or replace tissue. EGIS® is a resilient biocompatible implant, which is incorporated into the host tissue through cellular and microvascular infiltration.
- Inflammation: the body’s initial reaction to the implant.
- Regeneration: healing phase. Granulation tissue formation.
- Remodeling: replacement of the biological prosthesis with new connective tissue.
Advantages of Egis
Protection and regeneration of soft tissues in thorax-abdomen sites
EGIS® has excellent mechanical strength without the need for chemical reinforcement (cross-linking) which maximizes tissue regeneration. Thoracic wall defects, which historically were repaired with synthetic prostheses can now be treated successfully with biological matrices.
Incisional hernia treatment
EGIS® is designed to withstand the normal intra-abdominal pressures produced, including when under strain. Its natural biocompatibility allows intraperitoneal placement without fear of bowel adhesions. The concept of using surgical mesh to repair hernias was introduced more than 50 years ago. Repair with biological prosthesis is now widely recognized as superior to repair with direct suturing or synthetic prosthesis.
Prevention and treatment of parastomal hernia
The surgical treatment for parastomal hernias is closing of the defect by direct suturing or reinforcement with prosthesis. The prophylactic use of surgical mesh to close the defect at the time of the stoma’s creation is now widespread to prevent the onset of new hernias. A synthetic mesh implant in these indications is not recommended due to the high risk of skin erosion and fistula formation.
In association with VAC therapy
When the defect is too extensive for a primary closure, VAC therapy can be performed to allow healing of the wound by secondary intention by applying negative pressure to the site. EGIS® is indicated in association with this therapy, before the wound bed is ready for a skin graft which facilitates closure.