Native® is a cell-free, non-pyrogenic 0.6mm thick collagen matrix derived from porcine dermis (acellular dermal matrix ADM). The proprietary production process for Native® was developed to guarantee a completely natural, non cross linked product containing no chemical residue or preservatives which can amplify the inflammatory phenomenon and slow down tissue regeneration.
This surgical membrane is a resilient, biocompatible implant, which is incorporated into the host tissue through cellular and microvascular infiltration.
Recent studies have demonstrated that early complications with one-stage breast reconstruction depend on the extent and duration of the inflammatory response and that such a response is affected by the foreign body effect resulting from the implanted biomaterial.
A material like Native®which incorporates in the shortest time possible minimizes the risks of early complications.
One-stage breast reconstruction, when indicated, provides benefits both for the patient who onlyhas to undergoa single procedure, and for its significant cost savings. The advent of biomaterials has greatly contributed to this procedure by substantially improving aesthetic results.
The extracellular matrix structure is essential for the regenerative process since it acts as a target site for the transmembrane receptors that facilitate cell to extracellular matrix adhesion. These glycoproteins are present on the cell membrane. One of their most important functions is the role they play in cell migration. They determine the cell decision on which biological function it will perform and mediates the relationships between the extracellular matrix and the cell itself.
The main functions of the extracellular matrix are
- Facilitates cell migration
- Production of differentiated phenotype
- Accumulation and presentation of growth factors to target cells
- Scaffold for regeneration
The Native® porcine dermal matrix has been designed to minimise negative inflammatory phenomena such as fever, skin flare or prolonged seroma formation.
5 x magnification, highlighting the Collagen fibres of the matrix. Note Absence of cellular material
Histology demonstrating the remodeling process of Native® porcine matrix. In the upper part infiltration of fibroblasts and rich neovascularization can be seen